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XELODAcapecitabineis a fluoropyrimidine carbamate with antineoplastic activityIt is an orally administered systemic prodrug of 5deoxy-5-fluorouridine5DFURwhich is converted to 5fluorouracil.
Following oral administration of 1250 mg/m 2 capecitabine twice a day to cancer patients with varying degrees of renal impairmentpatients with moderatecreatinine clearance30 to 50 mL/minand severecreatinine clearance 80 mL/minSystemic exposure to 5DFUR was 42and 71greater in moderately and severely renal impaired patientsrespectivelythan in normal patientsSystemic exposure to capecitabine was about 25greater in both moderately and severely renal impaired patientssee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSWARNINGS AND PRECAUTIONSand Use In Specific Populations
A multicenter randomizedcontrolled phase 3 clinical trial in patients with DukesC colon cancerXACTprovided data concerning the use of XELODA for the adjuvant treatment of patients with colon cancerThe primary objective of the study was to compare disease-free survivalDFSin patients receiving XELODA to those receiving IV 5-FU/LV aloneIn this trial1987 patients were randomized either to buy alli 60mg online. treatment with XELODA 1250 mg/m 2 orally twice daily for 2 weeks followed by a 1-week rest periodgiven as 3-week cycles for a total of 8 cycles24 weeksor IV bolus 5-FU 425 mg/m 2 and 20 mg/m 2 IV leucovorin on days 1 to 5given as 4-week cycles for a total of 6 cycles24 weeksPatients in the study were required to be between 18 and 75 years of age with histologically-confirmed Dukesstage C colon cancer with at least one positive lymph node and to have undergonewithin 8 weeks prior to randomizationcomplete resection of the primary tumor without macroscopic or microscopic evidence of remaining tumorPatients were also required to have no prior cytotoxic chemotherapy or immunotherapyexcept steroidsand have an ECOG performance status of 0 or 1KPS70ANC1.5×10 9Lplatelets100x10 9Lserum creatinine1.5 ULNtotal bilirubin1.5 ULNAST/ALT2.5 ULN and CEA within normal limits at time of randomization.
The dose of XELODA used in the phase 3 clinical trial in combination with docetaxel was based on the results of a phase cheap diazepam from india, cheap diazepam from india, cheap diazepam from india, cheap diazepam from india, cheap diazepam from india, cheap diazepam from india. 1 studywhere a range of doses of docetaxel administered in 3-week cycles in combination with an intermittent regimen of XELODA14 days of treatmentfollowed by a 7-day rest periodwere evaluatedThe combination dose regimen was selected based on the tolerability profile of the 75 mg/m 2 administered in 3-week cycles of docetaxel in combination with 1250 mg/m 2 twice daily for 14 days of XELODA administered in 3-week cyclesThe approved dose of 100 mg/m 2 of docetaxel administered in 3-week cycles was the control arm of the phase 3 study.
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