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What is a package insertA package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumersA package insert typically includes information regarding specific indicationsadministration schedulesdosingside effectscontraindicationsresults from some clinical trialschemical structurepharmacokinetics and metabolism of the specific drugBy carefully reviewing the package insertyou will get the most complete and current information about how to safely use this drugIf you do not have the package discount rx. insert for the drug you are usingyour pharmacist or physician may be able to provide you with a copy.
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The composition of plasma radioactivityfollowing a single 200 mg oral dose of tritium-labeled flutamide to normal adult volunteersshowed that flutamide is rapidly and extensively metabolizedwith flutamide comprising only 2.5of plasma radioactivity 1 hour after administrationAt least six metabolites have been identified in plasmaThe major plasma metabolite is a biologically active alpha-hydroxylated derivative which accounts for 23of the plasma tritium 1 hour after drug administrationThe major urinary metabolite is 2-amino-5-nitro-4trifluoromethyl)phenol.
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