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But let me tell youit does have side effectsThe most common is a stickydry mouthfollowed by some suspected damage to the liver in the long run and lastlythe risk of seriously depriving the body of energyThese side effects are due to some of its constituentswhich are difficult to remove while processingStillsince hoodia products are herbal and most of its preparations do not contain harmful synthetic chemicals or stimulantsthey are safer than most of the weight loss drugs nitrofurantoin from canada. available in the market that put stress on the heart and metabolism.
BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
The plant is rich in pregnane glycosides containing 6-deoxyand 2,6-dideoxy-sugarsTo dateP57AS3P57is the only biologically active constituent from Hgordonii that has been reported to have anorexigenic activity5There is no evidence of P57 binding to or altering activity of known receptors or proteinsbut intracerebroventricular injections of P57 in rats has been reported to increase ATP content in the hypothalamuswhich might represent a signal of satiety and suppress appetitive responses6Howevera recent study claimed that P57 was not detectable in the brain upon oral administration in micewhich makes the mechanisms of action of P57 and Hgordonii more elusive7The development and commercialization of Hgordonii and P57 have been problematic due to controversy about intellectual property rights and limited natural resourcesin addition to the lack of a clear mechanismresulting in the withdrawal of several major pharmaceutical companies from Hoodia projects3Since the isolation of P57more new glycosidesincluding Gordonoside A-L8have been disclosed in the literature although their bioactivities remain unclear.
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